Three-Chambered Autoinjector

ABSTRACT

The present invention relates to a three-chambered autoinjector as well as to the methods of administering medicaments to a human using the three-chambered autoinjector. In certain embodiments, the autoinjector includes a first medicament in liquid form, a second medicament preferably in solid form, and a liquid composition for diluting the second medicament, and utilizes a three-chambered design so as to administer the first medicament and a solution comprising the second medicament and the liquid composition at different injection depths into the body of a human. In an alternative embodiment an autoinjector is provided that delivers medicaments at the same injection depth.

BACKGROUND

1. Technical Field

The present invention relates to an autoinjector with three chambers aswell as to methods of administering medicaments to a human using thethree-chambered autoinjector.

2. Background

Autoinjectors have become quite popular and have experienced widespreaduse due to a variety of advantages autoinjectors have over typicalmanual syringe injectors. A number of autoinjectors are commerciallyavailable, including EpiPen® (King Pharmaceuticals Inc.), Anapen®(Lincoln Medical Ltd.), Rebiject® II (EMD Serono and Pfizer Inc.), andSureClick™ (Amgen). Generally speaking, an autoinjector is an automaticinjection system that is designed to deliver a medicament into anindividual upon activation of a power assembly. Among other things,autoinjectors generally comprise a housing, a medicament situated withinthe housing, a needle, and a power assembly. After activation of thepower assembly, the needle moves from a storage position in which theneedle is situated within the housing to an active position in which theneedle extends from the housing and delivers the medicament to apatient.

There is a continuing need for improved autoinjector devices.

BRIEF SUMMARY

In one aspect, the present invention provides a three-chamberedautoinjector. The autoinjector includes a housing having a forward endand a rear end. In certain embodiments, the autoinjector furtherincludes an activateable power assembly, a rear plunger, a first chambercomprising a liquid composition, a separation assembly, a second chambercomprising a second medicament, a separation plunger, a third chambercomprising a first medicament, a needle, and a bypass within thehousing.

The first medicament is in a liquid form and, preferably, the secondmedicament is in a solid form, which can be dissolved in the liquidcomposition. More preferably, the second medicament is in a lyophilizedform.

In an alternative embodiment, both the first and the second medicamentsare in liquid forms.

The rear plunger is moveably situated in the housing and is operativelylinked to the power assembly so that after activation of the powerassembly, the power assembly moves the rear plunger forwardly within thehousing. The rear plunger rearwardly confines the first chamber.

The separation assembly is moveably situated in the housing andforwardly confines the first chamber and rearwardly confines the secondchamber. The separation assembly comprises a separation assembly bypasshaving a closed position in which the separation assembly bypassprohibits the liquid composition from flowing through the separationassembly and an open position for allowing the liquid composition toflow through the separation assembly and into the second chamber. Afteractivation of the power assembly, the separation assembly bypass movesfrom the closed position to the open position, allowing the liquidcomposition to enter the second chamber.

The separation plunger is moveably situated in the housing and forwardlyconfines the second chamber. After activation of the power assembly, theseparation plunger moves forwardly within the housing.

The third chamber is rearwardly confined by the separation plunger andcomprises a liquid medicament. In addition to the liquid medicament, thethird chamber comprises a gas such as air, so that after activation ofthe power assembly, the gas in the third chamber can be compressed andallow the separation plunger to move forwardly within the housing.

The autoinjector further includes a needle having a needle length, aforward end and a rear end. Prior to the activation of the powerassembly, the needle is in a needle storage position in which the needleis situated within the housing. After activation of the power assembly,the needle moves from the needle storage position to a needle fullyextended position in which the needle reaches a maximal extension out ofthe forward end of the housing.

A bypass within the housing is forwardly situated with respect to theseparation plunger prior to the activation of the power assembly and thebypass forms a bypass area within the housing for receiving theseparation plunger. Prior to the separation plunger entering into thebypass area, the separation plunger creates a seal so as to prevent asolution comprising the liquid composition and the second medicamentfrom flowing from the second chamber into the third chamber. When theseparation plunger is received in the bypass area, the separationplunger no longer creates a seal between the second chamber and thethird chamber and thus permits a solution comprising the liquidcomposition and the second medicament to flow around the separationplunger and into the needle.

The three-chambered design preferably enables all or substantially allof the liquid medicament to be delivered to a human as the needle movesfrom the needle storage position to the needle fully extended positionand the design enables a solution comprising the liquid composition andthe second medicament to be delivered after the needle reaches theneedle fully extended position. As a result, in a preferred embodiment,the medicaments are delivered at different injection depths so as toprevent the medicaments from affecting the absorption of one another inthe human's body.

Another advantage of the present invention is that it allows for theinclusion of more storage-stable forms (e.g., lyophilized forms) ofmedicaments that, when stored in liquid form, tend to become less pure,degrade and/or experience other unwanted effects.

Another advantage is that regulatory provisions in some jurisdictionsmay prohibit the storage of mixed cocktails of multiple medicaments, andthe present invention provides for separate storage of the medicamentsand the mixture of the medicaments immediately prior to injection.

In another embodiment of the invention, a moveable internal medicamenthousing has a needle assembly attached to the forward end thereof. Twoseparation assemblies are received in the internal medicament housingand separate it into three chambers.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 illustrates a side cross-sectional view of an autoinjector in aloaded, activateable state.

FIGS. 2-6 illustrate side cross-sectional views of an autoinjector afteractivation of the power assembly.

FIG. 7 illustrates a side schematic view and a side cross-sectional viewof an autoinjector needle resting on a concave surface of the separationplunger and further illustrates the flow of a medicament through theneedle.

FIG. 8 illustrates a top schematic view of an autoinjector needle andseparation plunger.

FIG. 9 is a side cross-sectional view of an alternative embodimenthaving a moveable internal medicament housing with two separationassemblies received in the internal medicament housing.

DETAILED DESCRIPTION

Referring now to the drawings, FIG. 1 illustrates a cross-sectional viewof one embodiment of an autoinjector generally designated by the numeral10. In the drawings, not all reference numbers are included in eachdrawing for the sake of clarity. In addition, positional terms such as“upper,” “lower,” “side,” “top,” “bottom,” etc. refer to the apparatuswhen in the orientation shown in the drawing. The skilled artisan willrecognize that the apparatus can assume different orientations when inuse.

Referring further to FIG. 1, the autoinjector 10 comprises a housing 12having a forward end 14 and a rear end 16. The housing 12 forms theexterior surface of the autoinjector body and can include one or morestructures. For example, in FIG. 1, the housing 12 comprises a safetypin 18, a cylindrical body 20 and a needle cover 22. The housing 12,preferably, is generally hollow and can be comprised of any material.Preferably, the housing 12 is plastic, but it could also be formed fromglass.

Situated within the housing 12 is an activateable power assembly 24.Power assemblies for autoinjector devices are well-known to those ofordinary skill and are described in, for example, U.S. Pat. No.7,449,012, the contents of which is incorporated herein by reference inits entirety. Preferably, the power assembly 24 comprises deformablecollet arms 26 and a spring 28. In certain embodiments, the powerassembly 24 is activated by removing the safety pin 18 and positioningthe autoinjector 10 on the body of a human. More particularly, incertain embodiments, the power assembly 24 is activated by removing thesafety pin 18 and pressing the forward end 14 of the autoinjectorhousing 12 against a desired injection site on a human's body.

FIG. 1 shows the autoinjector in a loaded, activateable state—i.e., thepower assembly 24 of the autoinjector 10 is capable of being activated,but has not been activated and the autoinjector 10 includes a firstmedicament in a liquid form, a second medicament, and a liquidcomposition so that the autoinjector 10 may deliver medicaments to apatient. The second medicament is preferably in a solid form and theliquid composition is for diluting the second (solid) medicament Thispreferred embodiment will be further described in the rest of thedescription.

However, it will be understood that the autoinjector 10 may include afirst medicament in a liquid form and a second medicament also in aliquid form.

It will also be appreciated that other states of the autoinjector 10,for example, prior to loading with medicaments and the liquidcomposition or after activation of the power assembly 24, are alsowithin the scope of the present invention. For example, FIGS. 2-6illustrate the autoinjector 10 after activation of the power assembly24.

Referring further to FIG. 1, the autoinjector 10 further includes a rearplunger 30 moveably situated within the housing 12. The rear plunger 30is operatively linked to the power assembly 24 so that after activationof the power assembly 24, the power assembly 24 moves the rear plunger30 forwardly within the housing 12.

The autoinjector 10 further includes a first chamber 32 comprising aliquid composition. The first chamber 32, and liquid compositioncontained therein, are rearwardly confined by the rear plunger 30. It isalso noted that the position of the rear plunger 30 relative to thepower assembly 24 may be adjusted to adjust the volume of the chamber32.

The autoinjector 10 further includes a separation assembly 34, which ismoveably situated in the housing 12 and forwardly confines the firstchamber 32. The separation assembly 34 comprises a separation assemblybypass 36, which has a closed position in which the separation assemblybypass 36 prohibits a liquid composition contained in the first chamber32 from flowing through the separation assembly 34 and an open positionfor allowing a liquid composition contained in the first chamber 32 toflow through the separation assembly 34 and forwardly within the housing12. After activation of the power assembly 24, the separation assemblybypass 36 moves from the closed position to the open position, allowingthe liquid composition to flow from the first chamber 32, through theseparation assembly 34 and forwardly within the housing 12.

Separation assembly bypasses for autoinjector devices are described in,for example, U.S. Patent Publication No. 2004/0097874, the contents ofwhich is incorporated by reference in its entirety.

The autoinjector 10 further includes a second chamber 38 comprising asolid medicament. The second chamber 38, and solid medicament containedtherein, are rearwardly confined by the separation assembly 34. Incertain embodiments, the solid medicament is in powder form. Preferably,the solid medicament is a lyophilized medicament—i.e., a medicament thathas been subjected to lyophilization, otherwise known as freeze-drying.The solid medicament is referred to herein as “the second medicament”,as it is the second medicament to be delivered from the autoinjector 10to a patient.

The liquid composition included in the first chamber 32 and the secondmedicament included in the second chamber 38 are selected so that thesecond medicament is soluble in the liquid composition, because, uponopening of the separation assembly bypass 36, the liquid compositionflows into the second chamber 38 and mixes with, and dissolves, thesecond medicament so as to create a solution comprising the secondmedicament and the liquid composition. Preferably, the liquidcomposition is an aqueous solution. In certain embodiments, the liquidcomposition included in the first chamber 32 comprises a medicament,thus, allowing the autoinjector 10 to deliver three medicaments to apatient.

In addition, in certain alternative embodiments, instead of a medicamentin solid form, the second chamber 38 can comprise a liquid medicament.In such embodiments, upon opening of the separation assembly bypass 36,the liquid composition flows into the second chamber 38 and mixes withthe liquid medicament in the second chamber 38 so as to form a solutioncomprising the liquid medicament and the liquid composition.

The autoinjector 10 further includes a separation plunger 40, which ismoveably situated within the housing and forwardly confines the secondchamber 38. After activation of the power assembly 24 and after theliquid composition begins to move through the separation assembly 34 andinto the second chamber 38, the separation plunger 40 moves forwardlywithin the housing 10.

The autoinjector 10 further includes a third chamber 42 comprising aliquid medicament. The third chamber 42, and liquid medicament containedtherein, are rearwardly confined by the separation plunger 40. Theliquid medicament is referred to herein as “the first medicament”, as itis the first medicament to be delivered from the autoinjector 10 to apatient. In addition to the first medicament, the third chamber 42comprises a gas which may be air but is preferably an inert gas, so thatafter activation of the power assembly 24, the gas in the third chamber42 can be compressed and allow the separation plunger 40 to moveforwardly within the housing 12.

The autoinjector 10 further includes a needle 44 having a needle length45, a forward end 48 and a rear end 46. As shown, in FIG. 1, the needle44 is in a needle storage position in which the needle 44 is situatedwithin the housing 12. After activation of the power assembly 24, theneedle 44 moves from the needle storage position to a needle fullyextended position in which the needle 44 reaches a maximal extension outof the forward end of the housing 12.

As shown in FIG. 1, preferably, the needle cover 22 comprises apunctureable sheath 50 situated over the forward end 48 of the needle 44so that the needle 44 can puncture through the sheath 50 and extend fromthe housing 12 after activation of the power assembly 24. It is alsopossible in some embodiments of a triple chamber autoinjector to have aneedle sheath that would be manually removed prior to use.

An illustrative needle for use in the present invention is shown inFIGS. 7 and 8. As shown, the needle 44 comprises a needle base 52, aninterior 54, an exterior 56, a first opening 58 for allowing the firstmedicament and a solution comprising the second medicament and theliquid composition to enter into the interior 54 of the needle 44 fromthe housing 12, a second opening 60 for allowing the first medicamentand the solution to be ejected from the needle 44, and a passage 62 forallowing the first medicament and the solution to flow through theinterior 54 of the needle 44 by entering through the first opening 58and exiting from the second opening 60. The needle base 52 preferablyrests on, but does not cover, a concave surface 64 of the separationplunger 40, which allows the first medicament and the solution to flowinto an area between the needle base 52 and the concave surface 64 ofthe separation plunger 40, enter into the first opening 58 in the needle44, through the needle passage 62, and exit from the second opening 60in the needle 44. In this embodiment, the first opening 58 of the needle44 is located in the needle base 52.

However, it will be understood that other embodiments can be used in thepresent invention. For example, the first opening 58 of the needle 44can be forwardly situated with respect to the base 52 and can comprisemultiple slits located around the needle 44.

The autoinjector 10 further includes a bypass 65 within the housing 12.The bypass 65 is forwardly situated with respect to the separationplunger 40 prior to the activation of the power assembly 24 and thebypass 65 forms a bypass area 66 within the housing 12 for receiving theseparation plunger 40. The bypass 65 may be in the form of groovesdefined in the housing wall, an enlarged internal diameter of thehousing wall, ribs extending inward from the housing wall, a cage-likeinsert received in the housing, or any combination of such structuresadequate to permit fluid to flow around the separation plunger 40 whenthe separation plunger 40 is received in the bypass area 66. Prior tothe separation plunger 40 entering into the bypass area 66, theseparation plunger 40 creates a seal so as to prevent a solutioncomprising the liquid composition and the second medicament from flowingfrom the second chamber 38 into the third chamber 42. When theseparation plunger is received in the bypass area 66, the separationplunger 40 no longer creates a seal between the second chamber 38 andthe third chamber 42, thus, permitting a solution comprising the liquidcomposition and the second medicament to flow around the separationplunger 40 and into the first opening 58 in the needle 44.

An exemplary mode of operation and method of use is described below foran autoinjector loaded with the first medicament, the second medicament,and the liquid composition. It will be understood that the method ofoperation and method of use is only exemplary.

An autoinjector 10 is provided. The autoinjector is in its loaded,activateable state. See FIG. 1.

The safety pin 18 is removed and the forward end 14 of the autoinjectorhousing 12 is pressed against a desired injection site on the body of ahuman. The deformable collet arms 26 collapse to release energy from thespring 28. See FIG. 2. It is noted that the autoinjector may also beconstructed to be activated by a push-button rather than by pressing ofthe autoinjector against the injection site.

The spring energy causes the rear plunger 30 to begin moving forwardlywithin the housing 12. The forwardly movement of the rear plunger 30decreases the volume of and pressurizes the first chamber 32. Thepressure built up within the first chamber 32 causes the separationassembly bypass 36 to move to the open position and the liquidcomposition to flow through the separation assembly 34 and into thesecond chamber 38. See FIG. 3.

The liquid composition begins to dissolve the second medicament to forma solution comprising the liquid composition and the second medicament.The liquid composition applies pressure on the separation plunger 40,causing the separation plunger 40 to move forwardly within the housing12. The forwardly movement of the separation plunger 40, in turn,decreases the volume of, and compresses gas in, the third chamber 42 andcauses the needle 44 to begin moving from the needle storage position tothe needle fully extended position. As the needle 44 moves from theneedle storage position to the needle fully extended position, the firstmedicament enters into the first opening 58 in the needle, flows throughthe passage 62 in the needle 44 and is ejected from the second opening60 in the needle 44 and into the body of a human. The rear plunger 30continues moving forwardly and aids the dissolution of the secondmedicament in the liquid composition. See FIG. 4; FIG. 7 (illustratingflow of a medicament through the needle).

The separation plunger 40 is received in the bypass area 66 and ceasesmoving forwardly within the housing 12. The needle 44 reaches the needlefully extended position and the first medicament ceases flowing throughthe passage 62 in the needle 44. A solution comprising the liquidcomposition and the second medicament flows from the second chamber 38,around the separation plunger 40, into the third chamber 42, and throughthe passage 62 in the needle 44. As the second medicament flows throughthe passage 62 in the needle 44, the rear plunger 30 and separationassembly 34 move forwardly within the housing 12. The forwardly movementof the separation assembly 34 decreases the volume of the second chamber38. See FIG. 5; FIG. 7 (illustrating flow of a medicament through theneedle).

The rear plunger 30 and the separation assembly 34 cease movingforwardly and the solution comprising the liquid composition and thesecond medicament ceases ejecting from the needle 44. The delivery ofthe medicaments is complete. Preferably, when the delivery of themedicaments is complete, the volumes of the first chamber 32, the secondchamber 38, and the third chamber 42 have approached zero, which ensuresthat little to no medicaments remain in the autoinjector 10 when thedelivery of the medicaments is complete. See FIG. 6.

As mentioned, the design of the autoinjector 10 allows the autoinjector10 to administer the first medicament and a solution comprising thesecond medicament and the liquid composition at different injectiondepths into the body of a human. More particularly, due to the sealcreated by the separation plunger 40 prior to entering the bypass area66, the autoinjector 10 delivers the first medicament as the needle 44moves from the needle storage position to the needle fully extendedposition. The autoinjector 10 delivers a solution comprising the secondmedicament and the liquid composition after the needle 44 moves to thefully extended position. It will be appreciated that a small amount ofthe first medicament may be ejected from the needle 44 after the needle44 moves to the needle fully extended position, as the solutioncomprising the second medicament and the liquid composition may washresidual amounts of the first medicament through the needle 44. However,preferably substantially all of the first medicament is delivered beforethe needle 44 reaches the needle fully extended position.

The Embodiment of FIG. 9

In FIG. 9 an alternative embodiment of the autoinjector is generallyindicated by the numeral 100. In FIG. 9 parts identical to or analogousto those of the autoinjector 10 of FIG. 1 are labeled with likenumerals.

The autoinjector 100 includes an external housing assembly 102 and amoveable internal medicament housing 104. The rear plunger 30 and thefirst separation assembly 34 are received in the bore of the internalmedicament housing 104. Also received in the internal medicament housing104 in place of the separation plunger 40 is a second separationassembly 106, which includes a bypass 108. A needle assembly 110includes a needle hub 112 attached to the forward end of moveableinternal medicament housing 104 for movement therewith relative to theexternal housing 102. The needle assembly 110 further includes a needle116 and a collapsible needle sheath 118.

The chambers 32, 38 and 42 may contain medicaments and/or liquidcompositions as previously described. A forward end of the third chamber42 is preferably sealed by a burstable membrane 114.

In operation the autoinjector 100 functions generally as follows. Theforward end of the external housing 104 is placed against a desiredinjection site on the body of the human. A push button actuator 115 isthen pressed to release the spring 28.

The spring energy causes the rear plunger 30 to begin moving forwardlywithin the internal medicament housing 104. The bypass 36 of the firstseparation assembly 34 opens and the liquid composition flows from firstchamber 32 through first separation assembly 34 into second chamber 38and begins to dissolve the second medicament. Once second chamber 38fills with liquid composition the hydraulic pressure applied on secondseparation assembly 106 will open second bypass 108 and will beginmoving the entire internal medicament housing 104 and needle assembly110 forward.

The sheath 118 will collapse and the needle 116 will pierce the end ofthe collapsible needle sheath 118 and will extend from the externalhousing 102 to its full insertion depth into the human. The medicamentfrom the third chamber 42 and the dissolved medicament from secondchamber 38 will flow substantially sequentially through the needle 116into the human at the full needle insertion depth.

Having now described the invention in accordance with the requirementsof the patent statutes, those skilled in the art will understand how tomake changes and modifications to the disclosed embodiments to meettheir specific requirements or conditions. Changes and modifications maybe made without departing from the scope and spirit of the invention, asdefined and limited solely by the following claims.

1. Autoinjector comprising: a) a housing having a forward end and a rear end; b) a rear plunger moveably situated within the housing; c) a separation assembly moveably situated within the housing, the separation assembly forwardly situated with respect to the rear plunger; d) a separation plunger moveably situated within the housing, the separation plunger forwardly situated with respect to the separation assembly; e) a first medicament situated forwardly with respect to the separation plunger, the first medicament in the form of a liquid; f) a second medicament situated between the separation plunger and the separation assembly; g) a liquid composition situated between the separation assembly and the rear plunger; h) a needle having a needle length, a forward end and a rear end, the needle being moveable from a needle storage position in which the needle is situated within the housing to a needle fully extended position in which the needle reaches a maximal extension out of the forward end of the housing; and i) an activateable power assembly for moving the rear plunger forwardly within the housing.
 2. Autoinjector according to claim 1, wherein, after activation of the power assembly, the power assembly causes the separation plunger, the separation assembly, and the rear plunger to move forwardly within the housing and the needle to move from the needle storage position to the needle fully extended position.
 3. Autoinjector according to claim 1 or 2, wherein the separation assembly comprises a separation assembly bypass, the separation assembly bypass having a closed position in which the separation assembly bypass prohibits the liquid composition from flowing through the separation assembly and mixing with the second medicament and an open position for allowing the liquid composition to flow through the separation assembly and mix with the second medicament.
 4. Autoinjector according to anyone of claims 1 to 3, wherein the housing comprises a punctureable sheath situated over the forward end of the needle so that the needle can puncture through the sheath and extend from the housing after activation of the power assembly.
 5. Autoinjector according to anyone of claims 1 to 4, wherein the needle comprises an interior, an exterior, a first opening for allowing the first medicament and a solution comprising the liquid composition and the second medicament to enter into the interior of the needle from the housing, a second opening for allowing the first medicament and the solution to be ejected from the needle, and a passage for allowing the first medicament and the solution to flow through the interior of the needle by entering through the first opening and exiting from the second opening.
 6. Autoinjector according to anyone of claims 1 to 5, wherein the autoinjector further comprises a bypass within the housing, the bypass forwardly situated with respect to the separation plunger prior to the activation of the power assembly, the bypass forming a bypass area within the housing for receiving the separation plunger so that when the separation plunger is received in the bypass area, a solution comprising the liquid composition and the second medicament can flow around the separation plunger and into an opening in the needle.
 7. Autoinjector according to anyone of claims 1 to 6, wherein the separation plunger rearwardly confines the first medicament.
 8. Autoinjector according to anyone of claims 1 to 7, wherein the second medicament is in the form of a solid.
 9. Autoinjector according to claim 8, wherein the second medicament is a lyophilized medicament.
 10. Autoinjector according to anyone of claims 1 to 9, wherein the liquid composition is an aqueous solution.
 11. Autoinjector having three chambers, the autoinjector comprising: a) a housing having a forward end and a rear end; b) a rear plunger moveably situated within the housing; c) a separation assembly moveably situated within the housing, the separation assembly forwardly situated with respect to the rear plunger; d) a separation plunger moveably situated within the housing, the separation plunger forwardly situated with respect to the separation assembly; e) a first chamber for a liquid composition, the first chamber having a variable volume, the first chamber forwardly confined by the separation assembly and rearwardly confined by the rear plunger; f) a second chamber for a second medicament, the second chamber having a variable volume, the second chamber forwardly confined by the separation plunger and rearwardly confined by the separation assembly; g) a third chamber for a first medicament, the third chamber having a variable volume, the third chamber rearwardly confined by the separation plunger; h) a needle having a needle length, a forward end and a rear end, the needle being moveable from a needle storage position in which the needle is situated within the housing to a needle fully extended position in which the needle reaches a maximal extension out of the forward end of the housing; and i) an activateable power assembly for moving the rear plunger forwardly within the housing.
 12. Autoinjector according to claim 11, wherein, after activation of the power assembly, the power assembly causes i) the rear plunger to move forwardly within the housing so as to decrease the volume of the first chamber; ii) the separation assembly to move forwardly within the housing so as to decrease the volume of the second chamber; iii) the separation plunger to move forwardly within the housing so as to decrease the volume of the third chamber; and iv) the needle to move from the needle storage position to the needle fully extended position.
 13. Autoinjector according to claim 11 or 12, wherein the separation assembly comprises a separation assembly bypass for allowing the liquid composition to flow from the first chamber through the separation assembly and into the second chamber.
 14. Autoinjector according to anyone of claims 11 to 13, including a first medicament contained in the third chamber, the first medicament in the form of a liquid.
 15. Autoinjector according to anyone of claims 11 to 14, including a second medicament contained in the second chamber, the second medicament in the form of a solid.
 16. Autoinjector according to anyone of claims 11 to 15, including a liquid composition contained in the first chamber.
 17. Method of administering a first medicament at a first depth and a second medicament at a second depth into the body of a human using an autoinjector, the method comprising the steps of a) providing an autoinjector comprising i) a housing having a forward end and a rear end; ii) a rear plunger moveably situated within the housing; iii) a separation assembly moveably situated within the housing, the separation assembly forwardly situated with respect to the rear plunger; iv) a separation plunger moveably situated within the housing, the separation plunger forwardly situated with respect to the separation assembly; v) a first medicament situated forwardly with respect to the separation plunger, the first medicament in the form of a liquid; vi) a second medicament situated between the separation plunger and the separation assembly; vii) a liquid composition situated between the separation assembly and the rear plunger; viii) a needle having a needle length, a forward end and a rear end, the needle being moveable from a needle storage position in which the needle is situated within the housing to a needle fully extended position in which the needle reaches a maximal extension out of the forward end of the housing; and ix) an activateable power assembly; b) positioning the autoinjector on the body of the human; c) activating the power assembly of the autoinjector.
 18. Method according to claim 17, wherein the second medicament is in the form of a solid.
 19. Method according to claim 18, wherein: the separation assembly comprises a separation assembly bypass, the separation assembly bypass having a closed position in which the separation assembly bypass prohibits the liquid composition from flowing through the separation assembly and mixing with the second medicament and an open position for allowing the liquid composition to flow through the separation assembly and mix with the second medicament; and further comprising: after step (c), opening the separation assembly bypass and flowing the liquid composition through the separation assembly to dissolve the second medicament.
 20. Method according to anyone of claims 17 to 19, further comprising: moving the separation plunger and the needle forwardly within the housing in response to pressure applied on the separation plunger by the liquid composition.
 21. Method according to anyone of claims 17 to 20, wherein the needle comprises an interior, an exterior, a first opening for allowing the first medicament and a solution comprising the liquid composition and the second medicament to enter into the interior of the needle from the housing, a second opening for allowing the first medicament and the solution to be ejected from the needle, and a passage for allowing the first medicament and the solution to flow through the interior of the needle by entering through the first opening and exiting from the second opening; the method further comprising: after step (c), moving the needle from the needle storage position to the needle fully extended position; and ejecting the first medicament through the second opening in the needle and into the body of the human as the needle moves from the needle storage position to the needle fully extended position.
 22. Method according to anyone of claims 17 to 21, wherein the needle comprises an interior, an exterior, a first opening for allowing the first medicament and a solution comprising the liquid composition and the second medicament to enter into the interior of the needle from the housing, a second opening for allowing the first medicament and the solution to be ejected from the needle, and a passage for allowing the first medicament and the solution to flow through the interior of the needle by entering through the first opening and exiting from the second opening, and wherein the autoinjector further comprises a bypass within the housing, the bypass forwardly situated with respect to the separation plunger prior to the activation of the power assembly, the bypass forming a bypass area within the housing for receiving the separation plunger so that when the separation plunger is received in the bypass area, a solution comprising the liquid composition and the second medicament can flow around the separation plunger and into the first opening in the needle; the method further comprising: after the separation plunger moves into the bypass area, flowing the solution into the first opening in the needle, through the passage in the needle and ejecting the solution from the second opening in the needle into the body of the human.
 23. Method according to claim 22, further comprising: moving the rear plunger and the separation assembly forwardly within the housing as the solution flows through the passage in the needle.
 24. Method according to claim 23, wherein the second medicament is in the form of a solid, the method further comprising: during the forward movement of the rear plunger, dissolving the second medicament in the liquid composition.
 25. Method according to claim 23 or 24, further comprising: ceasing the forward movement of the separation assembly within the housing and ceasing the flow of the solution through the passage in the needle.
 26. Method according to anyone of claims 17 to 25, further comprising after step (c), moving the needle from the needle storage position to the needle fully extended position.
 27. Method according to claim 26, further comprising: during the movement of the needle from the needle storage position to the needle fully extended position, delivering the first medicament into the body of the human; and after the movement of the needle to the needle fully extended position, delivering a solution comprising the liquid composition and the second medicament into the body of the human.
 28. Autoinjector comprising a liquid medicament, a solid medicament and a liquid composition, the autoinjector comprising: a) an external housing having a forward end and a rear end; b) an internal medicament housing moveably received in the external housing; c) a rear plunger moveably situated within the internal medicament housing; d) a first separation assembly moveably situated within the internal medicament housing, the first separation assembly forwardly situated with respect to the rear plunger; e) a second separation assembly moveably situated within the internal medicament housing, the second separation assembly forwardly situated with respect to the first separation assembly; f) a first medicament situated forwardly with respect to the second separation assembly, the first medicament in the form of a liquid; g) a second medicament situated between the second separation assembly and the first separation assembly, the second medicament in the form of a solid; h) a liquid composition situated between the first separation assembly and the rear plunger; i) a needle having a needle length, a forward end and a rear end, the needle being attached to a forward end of the internal medicament housing; and j) an activateable power assembly for moving the rear plunger forwardly within the internal medicament housing. 